Phthalocyanine-DNA origami complexes with enhanced stability and optical properties

In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggre...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (53), p.7341-7344
Main Authors: Shaukat, Ahmed, Anaya-Plaza, Eduardo, Julin, Sofia, Linko, Veikko, Torres, Tomas, de la Escosura, Andrés, Kostiainen, Mauri A
Format: Article
Language:English
Subjects:
Agglomeration
Biocompatible Materials - chemistry
Deoxyribonucleic acid
DNA
DNA - chemistry
Gels
Humans
Indoles - chemistry
Nanocapsules - chemistry
Optical microscopy
Optical properties
Oxidants, Photochemical - chemistry
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Singlet oxygen
Singlet Oxygen - chemistry
Static Electricity
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g. , photocatalysis, diagnositic arrays and photodynamic therapy. Cationic phthalocyanines bind DNA origami nanostructures, which protects them against enzymatic degradation and enhances the optical properties of the phthalocyanines.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc01916j