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Phthalocyanine-DNA origami complexes with enhanced stability and optical properties
In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggre...
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| Published in: | Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (53), p.7341-7344 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c399t-ad058f97a6fd1da97485e4922d21813547417a304c663e26154cc5642fc541543 |
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| cites | cdi_FETCH-LOGICAL-c399t-ad058f97a6fd1da97485e4922d21813547417a304c663e26154cc5642fc541543 |
| container_end_page | 7344 |
| container_issue | 53 |
| container_start_page | 7341 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 56 |
| creator | Shaukat, Ahmed Anaya-Plaza, Eduardo Julin, Sofia Linko, Veikko Torres, Tomas de la Escosura, Andrés Kostiainen, Mauri A |
| description | In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen,
e.g.
, photocatalysis, diagnositic arrays and photodynamic therapy.
Cationic phthalocyanines bind DNA origami nanostructures, which protects them against enzymatic degradation and enhances the optical properties of the phthalocyanines. |
| doi_str_mv | 10.1039/d0cc01916j |
| format | article |
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e.g.
, photocatalysis, diagnositic arrays and photodynamic therapy.
Cationic phthalocyanines bind DNA origami nanostructures, which protects them against enzymatic degradation and enhances the optical properties of the phthalocyanines.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc01916j</identifier><identifier>PMID: 32483566</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Agglomeration ; Biocompatible Materials - chemistry ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; Gels ; Humans ; Indoles - chemistry ; Nanocapsules - chemistry ; Optical microscopy ; Optical properties ; Oxidants, Photochemical - chemistry ; Photochemotherapy ; Photodynamic therapy ; Photosensitizing Agents - chemistry ; Singlet oxygen ; Singlet Oxygen - chemistry ; Static Electricity ; Structure-Activity Relationship</subject><ispartof>Chemical communications (Cambridge, England), 2020-07, Vol.56 (53), p.7341-7344</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-ad058f97a6fd1da97485e4922d21813547417a304c663e26154cc5642fc541543</citedby><cites>FETCH-LOGICAL-c399t-ad058f97a6fd1da97485e4922d21813547417a304c663e26154cc5642fc541543</cites><orcidid>0000-0002-8282-2379 ; 0000-0002-0928-8317 ; 0000-0001-9108-0912 ; 0000-0003-2762-1555 ; 0000-0001-9944-6907 ; 0000-0001-9335-6935 ; 0000-0001-8516-3885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32483566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaukat, Ahmed</creatorcontrib><creatorcontrib>Anaya-Plaza, Eduardo</creatorcontrib><creatorcontrib>Julin, Sofia</creatorcontrib><creatorcontrib>Linko, Veikko</creatorcontrib><creatorcontrib>Torres, Tomas</creatorcontrib><creatorcontrib>de la Escosura, Andrés</creatorcontrib><creatorcontrib>Kostiainen, Mauri A</creatorcontrib><title>Phthalocyanine-DNA origami complexes with enhanced stability and optical properties</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen,
e.g.
, photocatalysis, diagnositic arrays and photodynamic therapy.
Cationic phthalocyanines bind DNA origami nanostructures, which protects them against enzymatic degradation and enhances the optical properties of the phthalocyanines.</description><subject>Agglomeration</subject><subject>Biocompatible Materials - chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>Gels</subject><subject>Humans</subject><subject>Indoles - chemistry</subject><subject>Nanocapsules - chemistry</subject><subject>Optical microscopy</subject><subject>Optical properties</subject><subject>Oxidants, Photochemical - chemistry</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Singlet oxygen</subject><subject>Singlet Oxygen - chemistry</subject><subject>Static Electricity</subject><subject>Structure-Activity Relationship</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUtLAzEUhYMotlY37pURd8JoMnnMZFmmPhEVVHA3pEnGSZmXSYr235vaWndmk1zOxzmXEwAOETxHEPMLBaWEiCM22wJDhBmJKcnetpdvyuMUEzoAe87NYDiIZrtggBOSYcrYEDw_Vb4SdScXojWtjicP46iz5l00JpJd09f6S7vo0_gq0m0lWqlV5LyYmtr4RSRaFXW9N1LUUW-7XltvtNsHO6WonT5Y3yPwenX5kt_E94_Xt_n4PpaYcx8LBWlW8lSwUiEleEoyqglPEpWgLKxOUoJSgSGRjGGdMESJlJSRpJSUhAGPwOnKN0R_zLXzxayb2zZEFglBHAcDzgJ1tqKk7Zyzuix6axphFwWCxbK_YgLz_Ke_uwAfry3n00arDfpbWACOVoB1cqP-fUDQT_7Ti16V-Bshg38n</recordid><startdate>20200702</startdate><enddate>20200702</enddate><creator>Shaukat, Ahmed</creator><creator>Anaya-Plaza, Eduardo</creator><creator>Julin, Sofia</creator><creator>Linko, Veikko</creator><creator>Torres, Tomas</creator><creator>de la Escosura, Andrés</creator><creator>Kostiainen, Mauri A</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-8282-2379</orcidid><orcidid>https://orcid.org/0000-0002-0928-8317</orcidid><orcidid>https://orcid.org/0000-0001-9108-0912</orcidid><orcidid>https://orcid.org/0000-0003-2762-1555</orcidid><orcidid>https://orcid.org/0000-0001-9944-6907</orcidid><orcidid>https://orcid.org/0000-0001-9335-6935</orcidid><orcidid>https://orcid.org/0000-0001-8516-3885</orcidid></search><sort><creationdate>20200702</creationdate><title>Phthalocyanine-DNA origami complexes with enhanced stability and optical properties</title><author>Shaukat, Ahmed ; 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The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen,
e.g.
, photocatalysis, diagnositic arrays and photodynamic therapy.
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| ispartof | Chemical communications (Cambridge, England), 2020-07, Vol.56 (53), p.7341-7344 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Agglomeration Biocompatible Materials - chemistry Deoxyribonucleic acid DNA DNA - chemistry Gels Humans Indoles - chemistry Nanocapsules - chemistry Optical microscopy Optical properties Oxidants, Photochemical - chemistry Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Singlet oxygen Singlet Oxygen - chemistry Static Electricity Structure-Activity Relationship |
| title | Phthalocyanine-DNA origami complexes with enhanced stability and optical properties |
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