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Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular, NIS-Me and CRNS display outstanding phototoxicity toward HeLa cells under two-photon ex...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (77), p.11489-11492
Main Authors: Nguyen, Van-Nghia, Park, Sang Jun, Qi, Sujie, Ha, Jeongsun, Heo, Seonye, Yim, Yubin, Baek, Gain, Lim, Chang Su, Lee, Dong Joon, Kim, Hwan Myung, Yoon, Juyoung
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Language:English
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Summary:Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular, NIS-Me and CRNS display outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity. An effective approach to the design of photosensitizers was proposed and applied in two-photon excited photodynamic therapy of cancer.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc04644b