Redox switching of an artificial transmembrane signal transduction system

Transmission of chemical signals across lipid bilayer membranes can be achieved using membrane-anchored molecules, where molecular motion across the bilayer is controlled by switching the polarity of two different head groups. An external redox signal delivered by ascorbic acid was used to trigger m...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-03, Vol.57 (17), p.2196-2198
Main Authors: Trevisan, Lucia, Kocsis, Istvan, Hunter, Christopher A
Format: Article
Language:English
Subjects:
Ascorbic acid
Chain dynamics
Fluorescence
Lipids
Membranes
Molecular motion
Signal transduction
Switching
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Summary:Transmission of chemical signals across lipid bilayer membranes can be achieved using membrane-anchored molecules, where molecular motion across the bilayer is controlled by switching the polarity of two different head groups. An external redox signal delivered by ascorbic acid was used to trigger membrane translocation in a synthetic transduction system. An external redox signal delivered by ascorbic acid was used to trigger membrane translocation in a synthetic transduction system.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc08322d