Degradable pH-responsive NIR-II imaging probes based on a polymer-lanthanide composite for chemotherapy

• Published in: Dalton transactions : an international journal of inorganic chemistry 2020-07, Vol.49 (27), p.9444-9453
• Main Authors: Feng, Miao, Wang, Yanxing, Lin, Bi, Peng, Xiangrong, Yuan, Ying, Tao, Xiaofeng, Lv, Ruichan
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biocompatibility; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Blood vessels; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemotherapy; Degradation; Diagnosis; Drug delivery systems; Drug Screening Assays, Antitumor; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent Dyes - pharmacology; Humans; Hydrogen-Ion Concentration; Infrared imaging; Infrared Rays; Lanthanoid Series Elements - chemistry; Lanthanoid Series Elements - pharmacology; Medical imaging; Mice; Microscopy; MPEG encoders; Nanocrystals; Nanoparticles; Nanoparticles - chemistry; Near infrared radiation; Particle Size; Photoacoustic Techniques; Polydimethylsiloxane; Polymers; Polymers - chemistry; Polymers - pharmacology; Scanning electron microscopy; Silicon dioxide; Silicone resins; Size distribution; Spleen; Substrates; Surface Properties
• ISSN: 1477-9226; 1477-9234
• DOI: 10.1039/d0dt02042g

In this research, a pH-sensitive degradable nanoprobe was designed by combining hydrophobic rare earth nanoparticles with biocompatible mPEG-PLGA nanomicelles for near infrared II (NIR-II) imaging-guided anti-tumor chemotherapy. The as-synthesized nanoprobes (about 300 nm) with a highly enhanced permeability and retention (EPR) effect show great potential in the diagnosis of solid tumors, providing new prospects for clinical tumor diagnosis. Then, the degradable composite probes increase the imaging sensitivity of the probe and allow for the slow release of the internal anti-tumor drugs, reducing the loss of the drug during delivery. Finally, ultra-small rare earth nanoparticles (about 6 nm) can be excreted after hydrolysis of the composite probe to reduce the enrichment of the inorganic nanoparticles in vivo . Thus, this degradable NIR-II imaging probe based on a polymer-lanthanide composite could be a promising candidate for preclinical cancer chemotherapy and surgery navigation under a single 808 nm laser. A pH-sensitive nanoprobe was proposed by combining hydrophobic rare earth nanoparticles with biocompatible nanomicelles for near infrared-II (NIR-II) imaging-guided chemotherapy.