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Single nanosheet can sustainably generate oxygen and inhibit respiration simultaneously in cancer cells
In a tumor, the abnormal cancer cell proliferation results in an insufficient O 2 supply, and meanwhile cancer cells consume O 2 very fast. The imbalance between a low oxygen supply and overwhelming oxygen consumption results in a low oxygen concentration in solid tumors. Therefore, in order to reli...
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Published in: | Materials horizons 2021-02, Vol.8 (2), p.597-65 |
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Main Authors: | , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In a tumor, the abnormal cancer cell proliferation results in an insufficient O
2
supply, and meanwhile cancer cells consume O
2
very fast. The imbalance between a low oxygen supply and overwhelming oxygen consumption results in a low oxygen concentration in solid tumors. Therefore, in order to relieve hypoxia in tumors, it is necessary to not only sustainably generate O
2
, but also inhibit mitochondrial respiration simultaneously. Here, we found that a single Ti
2
C(OH)
2
nanomaterial not only can sustainably generate O
2
but also simultaneously highly inhibits mitochondrial respiration
via
binding phosphorylation proteins onto the surface in cancer cells. Ce6 was linked onto Ti
2
C(OH)
2
, forming Ti
2
C(OH)
2
-Ce6. Ti
2
C(OH)
2
-Ce6 could highly relieve hypoxia in tumors
via
the combination of sustainable O
2
generation and respiration inhibition, produce enough
1
O
2
to kill cancer cells
via
PDT, and also effectively convert the absorbed light energy into thermal energy to kill cancer cell
via
PTT, thereby highly enhancing the cancer therapy.
Ti
2
C(OH)
2
can relieve the hypoxia in tumors
via
generating O
2
from endogenous H
2
O
2
and inhibiting mitochondrial respiratory in cancer cell. |
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ISSN: | 2051-6347 2051-6355 |
DOI: | 10.1039/d0mh01446j |