One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: a green method and mechanistic insight

The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl 2 ] 3 ). The reactions proceed smoothly at low temperatures for a short reaction time without the use of toxic and vo...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2021-02, Vol.45 (4), p.253-259
Main Authors: Nguyen, Vu Thanh, Nguyen, Hai Truong, Tran, Phuong Hoang
Format: Article
Language:English
Subjects:
Catalytic activity
Chemical reactions
Eutectics
Low temperature
Reaction time
Selectivity
Solvents
Synthesis
Zinc chloride
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl 2 ] 3 ). The reactions proceed smoothly at low temperatures for a short reaction time without the use of toxic and volatile organic solvents. Deep eutectic solvents are capable of not only allowing multicomponent reactions to proceed in high yield but also controlling the selectivity towards desired products. The mechanistic insight was examined by HRMS (ESI) to propose a plausible mechanism. Furthermore, [CholineCl][ZnCl 2 ] 3 can be recycled in up to three consecutive cycles with an insignificant loss of catalytic activity under the optimized conditions. The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl 2 ] 3 ).
ISSN:1144-0546
1369-9261
DOI:10.1039/d0nj05687a