Visible-light-enabled aerobic oxidative C-H functionalization of glycine derivatives using an organic photocatalyst: access to substituted quinoline-2-carboxylates

A practical visible-light-induced aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with olefins has been developed to efficiently synthesize quinoline-2-carboxylates. This metal-free process proceeds smoothly under mild conditions and exhibits good tolerance of functional g...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2020-10, Vol.18 (4), p.8179-8185
Main Authors: Wang, Jingxin, Li, Liqi, Guo, Ying, Li, Shengyu, Wang, Shutao, Li, Ying, Zhang, Yuan
Format: Article
Language:English
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Summary:A practical visible-light-induced aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with olefins has been developed to efficiently synthesize quinoline-2-carboxylates. This metal-free process proceeds smoothly under mild conditions and exhibits good tolerance of functional groups. Given the low cost of the catalyst and feedstock materials, the mild reaction conditions and the absence of hazardous byproducts, this protocol should find broad applications in the synthesis of quinoline-2-carboxylate derivatives. A metal-free visible-light-induced aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with olefins has been developed to efficiently synthesize quinoline-2-carboxylates.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob01837f