Highly-magnetic mineral protein-tannin vehicles with anti-breast cancer activity

Anticancer hybrid mineral highly-magnetic protein-tannin vehicles are tunable and controllable external triggers for drug delivery systems. The saturation level of submicron particles of calcium carbonate with magnetic nanoparticles was achieved. The Brillouin light scattering technique and the move...

Full description

Saved in:
Bibliographic Details
Published in:Materials chemistry frontiers 2021-02, Vol.5 (4), p.27-218
Main Authors: Demina, Polina A, Abalymov, Anatolii A, Voronin, Denis V, Sadovnikov, Alexandr V, Lomova, Maria V
Format: Article
Language:English
Subjects:
Breast cancer
Calcium carbonate
Composite materials
Computational fluid dynamics
Doxorubicin
Drug carriers
Drug delivery systems
Encapsulation
Freezing
Light scattering
Magnetic properties
Nanoparticles
Nonuniform magnetic fields
Proteins
Tannins
Vehicles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anticancer hybrid mineral highly-magnetic protein-tannin vehicles are tunable and controllable external triggers for drug delivery systems. The saturation level of submicron particles of calcium carbonate with magnetic nanoparticles was achieved. The Brillouin light scattering technique and the movement determination of composites in the non-uniform magnetic field, as well as the SEM study of hybrid mineral highly-magnetic composites, made it possible to characterize the magnetic properties of the carriers and determine that 3 freezing/thawing cycles of magnetic nanoparticles are sufficient to obtain an optimal drug carrier. We have demonstrated that doxorubicin and mitoxantrone are effectively encapsulated in vehicles, while the encapsulated drugs are effectively stored in clean water and PBS. Anticancer hybrid mineral highly-magnetic protein-tannin vehicles have a higher cytostatic effect on MCF-7 breast cancer cells because of the best interaction of the cytostatics with DNA due to the inside-out structure compared with the NMUMG breast healthy cell line. Extra magnetic anticancer structures of the core-shell can be potentially used as objects for preserving antitumor drugs over time, due to the higher survival rate compared to the pure substance and the lack of release of antitumor drugs into model fluids. Anticancer submicron hybrid highly saturated magnetic vehicles were obtained and characterized by brillouin light scattering technique. Obtained vehicles provided effective encapsulation of doxorubicin and mitoxantrone and showed a cytostatic effect on the cancer breast cells culture.
ISSN:2052-1537
2052-1537
DOI:10.1039/d0qm00732c