Pycnidiophorones A-D, four new cytochalasans from the wetland derived fungus

Pycnidiophorones A-D ( 1-4 ), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0 2,7 ]dodecane core, and six known depsidones ( 5-10 ) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa . Their chemical...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2020-11, Vol.1 (66), p.4384-439
Main Authors: Zhao, Chen, Liu, Gaoran, Liu, Xingzhong, Zhang, Lan, Li, Lin, Liu, Ling
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pycnidiophorones A-D ( 1-4 ), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0 2,7 ]dodecane core, and six known depsidones ( 5-10 ) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa . Their chemical structures were unambiguously determined using NMR spectroscopic data. The absolute configurations of 1 and 3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1-10 showed moderate cytotoxicity against a panel of five human tumor cell lines. Four new 5/6/6/5/6 pentacyclic cytochalasan pycnidiophorones A-D ( 1-4 ) and six known depsidones were identified from the wetland-soil-derived fungus Pycnidiophora dispersa .
ISSN:2046-2069
DOI:10.1039/d0ra08072a