Designing a highly stable coordination-driven metallacycle for imaging-guided photodynamic cancer theranostics

Coordination-driven self-assembly features good predictability and directionality in the construction of discrete metallacycles and metallacages with well-defined sizes and shapes, but their medicinal application has been limited by their low stability and solubility. Herein, we have designed and sy...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2020-08, Vol.11 (3), p.794-7949
Main Authors: He, Lizhen, Cai, Li-Xuan, Li, Meng-Hua, Zhang, Guang-Lu, Zhou, Li-Peng, Chen, Tianfeng, Lin, Mei-Jin, Sun, Qing-Fu
Format: Article
Language:English
Subjects:
Biocompatibility
Cancer
Chemistry
Coordination
Crystallography
Diimide
Fluorescence
Imaging
Organometallic compounds
Oxygen production
Self-assembly
Singlet oxygen
Stability
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Summary:Coordination-driven self-assembly features good predictability and directionality in the construction of discrete metallacycles and metallacages with well-defined sizes and shapes, but their medicinal application has been limited by their low stability and solubility. Herein, we have designed and synthesized a highly stable coordination-driven metallacycle with desired functionality derived from a perylene-diimide ligand via a spontaneous deprotonation self-assembly process. Brilliant chemical stability and singlet oxygen production ability of this emissive octanuclear organopalladium macrocycle make it a good candidate toward biological studies. After cellular uptake by endocytosis, the metallacycle exhibits potent fluorescence cell imaging properties and cancer photodynamic therapeutic ability through enhancing ROS production, with high biocompatibility and safety. This study not only provides a rational design strategy for highly stable luminescent organopalladium metallacycles, but also sheds light on their application in imaging-guided photodynamic cancer therapy. A highly-luminescent metallacycle with chemical stability and singlet oxygen production ability were obtained by a spontaneous deprotonation self-assembly process, which exhibits application potential in imaging-guided photodynamic cancer therapy.
ISSN:2041-6520
2041-6539
DOI:10.1039/d0sc02236e