Light-driven assembly of biocompatible fluorescent chitosan hydrogels with self-healing ability

Nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) was successfully used to cross-link complementary tetrazole and maleimide chitosan derivatives into hydrogel networks using irradiation. The photo-click reaction resulted in the formation of robust fluorescent hydrogels with an emission sign...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-11, Vol.8 (42), p.984-9811
Main Authors: Guaresti, Olatz, Crocker, Leander, Palomares, Teodoro, Alonso-Varona, Ana, Eceiza, Arantxa, Fruk, Ljiljana, Gabilondo, Nagore
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible Materials - chemistry
Biomaterials
Biomedical materials
Chemical reactions
Chitosan
Chitosan - chemistry
Crosslinking
Cycloaddition
Fluorescence
Fluorescent Dyes - chemistry
Hydrogels
Hydrogels - chemistry
Irradiation
Light
Maleimides - chemistry
Radiation
Rheological properties
Storage modulus
Tetrazoles
Tetrazoles - chemistry
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Summary:Nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) was successfully used to cross-link complementary tetrazole and maleimide chitosan derivatives into hydrogel networks using irradiation. The photo-click reaction resulted in the formation of robust fluorescent hydrogels with an emission signal at around 530 nm. The degree of cross-linking and the resulting hydrogel properties such as pH sensitivity and swelling were influenced by the tetrazole/maleimide ratio and the length of irradiation. Interestingly, rheological studies demonstrated self-healing character of the novel hydrogels as indicated by instantaneous recovery of the storage modulus to the initial values under different oscillatory strains without any additional external trigger. Finally, in addition to their photo-tuneable and self-healing properties, the novel chitosan hydrogels were also found to be biocompatible and susceptible to in vitro enzymatic degradation, making them suitable for design of traceable biomaterials for biomedical applications. Nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) was successfully used to cross-link complementary tetrazole and maleimide chitosan derivatives into hydrogel networks using irradiation.
ISSN:2050-750X
2050-7518
DOI:10.1039/d0tb01746a