Molecular diagnostics in the era of COVID-19

As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and understanding the epidemiology of this disease. A plethora of technologies have enabled the diagnosis of individuals, informed clinica...

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Bibliographic Details
Published in:Analytical Methods 2021-09, Vol.13 (34), p.3744-3763
Main Authors: Jayakody, Harindi, Kiddle, Guy, Perera, Semali, Tisi, Laurence, Leese, Hannah S
Format: Article
Language:English
Subjects:
Coronaviruses
COVID-19
Disease control
Disease transmission
Epidemiology
Humans
Mutation
Pandemics
Pathology, Molecular
SARS-CoV-2
Sensitivity and Specificity
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Summary:As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and understanding the epidemiology of this disease. A plethora of technologies have enabled the diagnosis of individuals, informed clinical management, aided population-wide screening to determine transmission rates and identified cases within the wider community and high-risk settings. This review explores the application of molecular diagnostics technologies in controlling the spread of COVID-19, and the key factors that affect the sensitivity and specificity of the tests used. As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and understanding the epidemiology of this disease.
ISSN:1759-9660
1759-9679
DOI:10.1039/d1ay00947h