Nematicidal activity of naphthalimide-boron cluster conjugates

This study presents the activity of a series of 1,8-naphthalimide-carborane/metallacarborane conjugates against Rhabditis sp. The carborane conjugates were the least active. Selected conjugates with cobaltacarborane (5 and 6) showed high activity. Their lethal concentration (LC 50 ) values are subst...

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Published in:Chemical communications (Cambridge, England) England), 2022-02, Vol.58 (15), p.2528-2531
Main Authors: Bogucka-Kocka, Anna, Ko odziej, Przemys aw, Makuch-Kocka, Anna, Ró ycka, Daria, Rykowski, Sebastian, Nekvinda, Jan, Grüner, Bohumír, Olejniczak, Agnieszka B
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Carborane
Conjugates
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container_title Chemical communications (Cambridge, England)
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creator Bogucka-Kocka, Anna
Ko odziej, Przemys aw
Makuch-Kocka, Anna
Ró ycka, Daria
Rykowski, Sebastian
Nekvinda, Jan
Grüner, Bohumír
Olejniczak, Agnieszka B
description This study presents the activity of a series of 1,8-naphthalimide-carborane/metallacarborane conjugates against Rhabditis sp. The carborane conjugates were the least active. Selected conjugates with cobaltacarborane (5 and 6) showed high activity. Their lethal concentration (LC 50 ) values are substantially lower than that of the drug mebendazole. The present work demonstrated the hitherto unknown biological activity of metallacarboranes.
doi_str_mv 10.1039/d1cc07075d
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source Royal Society of Chemistry Journals
subjects Carborane
Conjugates
title Nematicidal activity of naphthalimide-boron cluster conjugates
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