Fluorescence imaging of pathophysiological microenvironments

Abnormal microenvironments (viscosity, polarity, pH, etc. ) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. As a result, deep insights into these pathophysiological microenvironments are particularly...

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Bibliographic Details
Published in:Chemical Society reviews 2021-08, Vol.5 (16), p.8887-892
Main Authors: Wang, Shan, Ren, Wen Xiu, Hou, Ji-Ting, Won, Miae, An, Jusung, Chen, Xiaoyuan, Shu, Jian, Kim, Jong Seung
Format: Article
Language:English
Subjects:
Computed tomography
Fluorescent indicators
Magnetic resonance imaging
Medical imaging
Positron emission
Tomography
Viscosity
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Summary:Abnormal microenvironments (viscosity, polarity, pH, etc. ) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. As a result, deep insights into these pathophysiological microenvironments are particularly beneficial for clinical diagnosis and treatment. However, the monitoring of pathophysiological microenvironments is unattainable by the traditional clinical diagnostic techniques such as magnetic resonance imaging, computed tomography, and positron emission tomography. Recently, fluorescence imaging has shown tremendous advantages and potential in the tracing of pathophysiological microenvironment variations. In this context, a general discussion is provided on the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field. Abnormal microenvironments (viscosity, polarity, pH, etc. ) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer.
ISSN:0306-0012
1460-4744
DOI:10.1039/d1cs00083g