Ethidium bromide-bridged mesoporous silica hybrid nanocarriers for fluorescence cell imaging and drug delivery applications

Mesoporous silica nanocarriers with dual/multifunctionalities are thought to be good candidates for dual/multimodal applications such as combined drug delivery and bioimaging. In this study, new red fluorescent organosilica materials were conveniently produced with diurea-ethidium bromide (DU-EB) fu...

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Bibliographic Details
Published in:New journal of chemistry 2021-11, Vol.45 (44), p.2641-2648
Main Authors: Santhamoorthy, Madhappan, Thirupathi, Kokila, Periyasamy, Thirukumaran, Thirumalai, Dinakaran, Ramkumar, Vanaraj, Kim, Seong-Cheol
Format: Article
Language:English
Subjects:
Biocompatibility
Doxorubicin
Drug carriers
Fluorescence
Hybrid systems
Medical imaging
Silicon dioxide
Ultraviolet radiation
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Summary:Mesoporous silica nanocarriers with dual/multifunctionalities are thought to be good candidates for dual/multimodal applications such as combined drug delivery and bioimaging. In this study, new red fluorescent organosilica materials were conveniently produced with diurea-ethidium bromide (DU-EB) functional units integrated in the pore wall framework for simultaneous diagnosis and therapy. We found that the prepared mesoporous silica hybrid nanocarrier system exhibited strong red fluorescence under UV-light (365 nm) while retaining excellent photo- and chemical-stability. The integrated ethidium bromide functional units in the mesopore walls cause the red fluorescence. By loading/releasing doxorubicin (Dox)/5-fluorouracil (5-FU) as a model cargo, the synthesized DU-EB@MSH materials were tested at various pH levels (pH 5.0, 6.2 and 7.4), and the cytocompatibility of the red-fluorescent DU-EB@MSH nanocarrier system was assessed using human breast cancer (MCF-7) cells. The experimental results revealed that the drug release behavior is primarily determined by the pH of the intracellular medium, and red-fluorescence was induced by a UV-light (365 nm) trigger. All the study results suggested that the DU-EB@MSH drug carrier system could be useful for red-fluorescence bioimaging and chemotherapeutic applications in cancer therapy. We report the fabrication of mesoporous organosilica hybrid nanocarriers with red-fluorescence behaviour under UV-light for pH-responsive drug delivery and red-fluorescence-based bioimaging applications in cancer therapy.
ISSN:1144-0546
1369-9261
DOI:10.1039/d1nj03520g