Y(OTf)-catalyzed phosphorylation of 2-chromene hemiacetals with P(O)-H compounds to 2-phosphorylated 2-chromenes

A facile synthesis of 2-phosphorylated 2 H -chromenes has been accomplished herein via a Y(OTf) 3 -catalyzed dehydrative coupling of 2 H -chromene hemiacetals with P(O)-H compounds. This protocol features low catalyst loading, mild reaction conditions, broad substrate scope and easy elaboration of t...

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Published in:Organic & biomolecular chemistry 2021-08, Vol.19 (31), p.6812-6816
Main Authors: Zheng, Shi-Lu, Zou, Yun-Xiang, Wen, Zhong, Lin, Jia-Fu, Gu, Ling-Hui, Chen, Long
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Summary:A facile synthesis of 2-phosphorylated 2 H -chromenes has been accomplished herein via a Y(OTf) 3 -catalyzed dehydrative coupling of 2 H -chromene hemiacetals with P(O)-H compounds. This protocol features low catalyst loading, mild reaction conditions, broad substrate scope and easy elaboration of the products. A highly efficient dehydrative phosphorylation of 2 H -chromene hemiacetals with P(O)-H compounds was reported, which provides 2-phosphorylated 2 H -chromenes in rich diversity with up to 98% yield.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob01221e