Synthesis and sequencing of informational poly(amino phosphodiester)s

Sequence-defined poly(amino phosphodiester)s containing main-chain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry....

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Bibliographic Details
Published in:Polymer chemistry 2021-09, Vol.12 (37), p.5279-5282
Main Authors: Roszak, Ian, Oswald, Laurence, Al Ouahabi, Abdelaziz, Bertin, Annabelle, Laurent, Eline, Felix, Olivier, Carvin-Sergent, Isaure, Charles, Laurence, Lutz, Jean-François
Format: Article
Language:English
Subjects:
Amines
Chemical Sciences
Chemical synthesis
Mass spectrometry
Polymer chemistry
Polymers
Scientific imaging
Solid phases
Spectroscopy
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Summary:Sequence-defined poly(amino phosphodiester)s containing main-chain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry. These methods evidenced preparation of molecularly-defined polymers. Furthermore, the presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry. The inclusion of main-chain tertiary amines in digital poly(phosphodiester)s allows synthesis of molecularly-defined achiral polymers and simplifies tandem mass spectrometry sequencing.
ISSN:1759-9954
1759-9962
DOI:10.1039/d1py01052b