Synthesis, characterization, and evaluation of selective molecularly imprinted polymers for the fast determination of synthetic cathinones

• Published in: RSC advances 2021-09, Vol.11 (47), p.29752-29761
• Main Authors: Chen, Hong, Wu, Fangsheng, Xu, Yibing, Liu, Yuan, Song, Lun, Chen, Xiujuan, He, Qun, Liu, Wei, Han, Qiaoying, Zhang, Zihua, Zou, Yun, Liu, Wenbin
• Format: Article
• Language: English
• Subjects: Adsorption; Chemical synthesis; Chemistry; Crime; Endothermic reactions; Imprinted polymers; Polymers; Selectivity; Temperature dependence
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d1ra01330k

As a kind of new psychoactive substance (NPS), synthetic cathinones have drawn great worldwide attention. In this study, molecularly imprinted polymers (MIPs), as adsorbents for the extraction and determination of 4-methyldimethcathinone (4-MDMC), were first synthesized by coprecipitation polymerization. The physicochemical analyses of MIPs were successfully performed by XRD, FTIR, FESEM and TGA techniques. Furthermore, rebinding properties of temperature and pH dependence, and selectivity and reusability tests for MIPs and non-imprinted polymers (NIPs) were performed using an ultraviolet-visible spectrometer (UV-vis). The obtained results indicate that the imprinting efficiency has strong dependence on temperature and pH, and the optimal adsorption for targets is achieved under the condition of 318 K and pH = 6.0. This means that the combination between the polymers and 4-MDMC is a strong spontaneous and endothermic process. Compared with NIPs, MIPs exhibit prominent adsorption capacity ( Q e = 9.77 mg g −1 , 318 K). The selectivity coefficients ( k ) of MIPs for 4-MDMC, methylenedioxypentedrone (βk-MBDP), 4-ethylmethcathinone (4-EMC), methoxetamine (MXE) and tetrahydrofuranylfentanyl (THF-F) were found to be 1.70, 3.49, 7.14 and 5.82, respectively. Moreover, it was found that the adsorption equilibrium was achieved within 30 min. The aim of this work is the simple synthesis of MIPs and the optimal performance of the molecular recognition of 4-MDMC. Moreover, the synthesized MIPs can be easily regenerated and repeatedly used with negligible loss of efficiency (only 9.94% loss after six times adsorption-desorption tests). Satisfying recoveries in the range of 69.3-78.9% indicate that MIPs have good applicability for analyte removal from urine samples. Ultimately, this material shows great promise for the rapid extraction and separation of synthetic cathinones, which are dissolved in the liquid for the field of criminal sciences. Molecularly imprinted polymers, as an adsorbent for extraction and selective recognition of 4-methyldimethcathinone, were firstly synthesized through coprecipitation polymerization.