A novel three-dimensional molecularly imprinted polypyrrole electrochemical sensor based on MOF derived porous carbon and nitrogen doped graphene for ultrasensitive determination of dopamine

Herein, a novel molecular imprinting polypyrrole electrochemical sensor was fabricated based on a zirconia and carbon core-shell structure (ZrO 2 @C) and a nitrogen-doped graphene (NPG) modified glassy carbon electrode (GCE) for ultrasensitive recognition of dopamine (DA). The NPG was prepared by a...

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Bibliographic Details
Published in:Analyst (London) 2022-11, Vol.147 (22), p.5194-522
Main Authors: Bu, Liyin, Jiang, Ding, Song, Qingyuan, Shan, Xueling, Wang, Wenchang, Chen, Zhidong
Format: Article
Language:English
Subjects:
Binding sites
Carbon
Chemical sensors
Core-shell structure
Dopamine
Electrochemical analysis
Glassy carbon
Graphene
Imprinted polymers
Metal-organic frameworks
Molecular imprinting
Nitrogen
Polymerization
Polypyrroles
Pyrolysis
Recognition
Selectivity
Sensors
Zirconium dioxide
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Summary:Herein, a novel molecular imprinting polypyrrole electrochemical sensor was fabricated based on a zirconia and carbon core-shell structure (ZrO 2 @C) and a nitrogen-doped graphene (NPG) modified glassy carbon electrode (GCE) for ultrasensitive recognition of dopamine (DA). The NPG was prepared by a sacrificial-template-assisted pyrolysis method and ZrO 2 @C was synthesized via annealing treatment of a zirconium-based metal-organic framework (UiO-66). A convenient electropolymerization method was used to prepare the pyrrole (Py) conductive molecularly imprinted polymer (MIP) in the presence of DA. The elution process of DA was performed by a simple overoxidation process under alkaline conditions. Differential pulse voltammetry (DPV) was used to assess the electrochemical performance of the sensors. The MIP-based electrochemical sensor with specific binding sites could be used for selective recognition of DA. Under the optimal conditions, the linear range of such a sensor was 5.0 × 10 −9 -1.0 × 10 −4 mol L −1 and the detection limit was 3.3 × 10 −10 mol L −1 (S/N = 3). This sensor exhibited suitable selectivity, stability, and reproducibility, which suggested that it could be a promising candidate for rapid diagnostic methods in dopamine investigations. The fabrication processes of Ppy-MIP/ZrO 2 @C/NPG/GCE.
ISSN:0003-2654
1364-5528
DOI:10.1039/d2an01469f