DNA-catalysed alternative RNA splicing

We report DNA-catalysed alternative RNA splicing in vitro . Using modular DNA catalysts with RNA endonuclease and RNA ligase activities, we show that DNA can modulate RNA structure and activity. Furthermore, we illustrate that such DNA-catalysed reactions can yield, from a common precursor, differen...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-07, Vol.58 (55), p.7698-771
Main Authors: Wei, Dongying, Gao, Mingmei, Guo, Jiajie, Wang, Yueyao, Li, Xintong, Li, Zhe, Yu, Hanyang
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
Ribonucleic acid
RNA
Splicing
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Summary:We report DNA-catalysed alternative RNA splicing in vitro . Using modular DNA catalysts with RNA endonuclease and RNA ligase activities, we show that DNA can modulate RNA structure and activity. Furthermore, we illustrate that such DNA-catalysed reactions can yield, from a common precursor, different splicing isoforms with distinct functions. DNA can catalyse alternative RNA splicing reactions in vitro , and modulate RNA structure and function.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc00812b