Last-step F-fluorination of supported 2-(aryl-di--butylsilyl)--methyl-imidazole conjugates for applications in positron emission tomography

Aiming for potential applications in positron emission tomography, fully automated productions of 18 F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di- tert -butyl-arylsilanes to a polystyrene resin. The reactions were performed using either &quo...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-08, Vol.58 (65), p.914-9143
Main Authors: Steffann, Marine, Tisseraud, Marion, Bluet, Guillaume, Roy, Sebastien, Aubert, Catherine, Fouquet, Eric, Hermange, Philippe
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Summary:Aiming for potential applications in positron emission tomography, fully automated productions of 18 F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di- tert -butyl-arylsilanes to a polystyrene resin. The reactions were performed using either "batch" or "flow" procedures, avoiding both the time-consuming azeotropic drying and HPLC purifications usually required. Resin-supported imidazole-di- tert -butyl-arylsilanes are versatile precursors for the automated "in batch" or "in flow" production of 18 F-labelled bioconjugates.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03258a