Spatial characterization of redox processes and speciation of Ru() anticancer complexes by F magnetic resonance imaging

The application of CF 3 -labeled Ru( iii ) anticancer complexes to magnetic resonance (MR) imaging of tumour tissues is demonstrated. By combining anatomical chemical-shift selective (CHESS) imaging with 19 F chemical-shift imaging (CSI) MR methods, we show that oxidation states and ligand-exchange...

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Published in:Chemical communications (Cambridge, England) England), 2023-01, Vol.59 (5), p.623-626
Main Authors: MacNeil, Gregory A, Chang, Stephanie W, Prosser, Kathleen E, Ye, Eric, Heroux, Devon, Lewis, Andrew R, Bally, Marcel, Walsby, Charles J
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Summary:The application of CF 3 -labeled Ru( iii ) anticancer complexes to magnetic resonance (MR) imaging of tumour tissues is demonstrated. By combining anatomical chemical-shift selective (CHESS) imaging with 19 F chemical-shift imaging (CSI) MR methods, we show that oxidation states and ligand-exchange processes of the complexes can be spatially encoded. Measurements on different tissue models, including a human breast adenocarcinoma tumour, validate the application of these complexes as MR theranostics for the sensing and targeting of hypoxia. Fluorine labelling of a Ru( iii ) chemotherapeutic candidate enables studies of reactivity in tissues by 19 F nuclear magnetic resonance imaging methods.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc04830b