Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents

Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-11, Vol.58 (91), p.12676-12679
Main Authors: Wang, Meng-Fan, Deng, Yu-Ang, Li, Qing-Fang, Tang, Shi-Jie, Yang, Rong, Zhao, Run-Yu, Liu, Fu-Dan, Ren, Xiaoxia, Zhang, Dan, Gao, Feng
Format: Article
Language:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor photothermal therapy agent in vitro and in vivo . Mitochondrion-targeting dinuclear osmium complexes with extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser without nucleus affinity and photodynamic activity act as antitumor photothermal therapy agents in vivo .
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc05230j