Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids drying

We report the co-polymerization of glycol nucleic acid (GNA) monomers with unsubstituted and substituted dicarboxylic acid linkers under plausible early Earth aqueous dry-down conditions. Both linear and branched co-polymers are produced. Mechanistic aspects of the reaction and potential roles of th...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-06, Vol.59 (45), p.6865-6868
Main Authors: Yi, Ruiqin, Jia, Tony Z, Meringer, Markus, Marshall, Luke K, Chen, Chen, McGlynn, Shawn Erin, Fahrenbach, Albert C, Cleaves, H. James
Format: Article
Language:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the co-polymerization of glycol nucleic acid (GNA) monomers with unsubstituted and substituted dicarboxylic acid linkers under plausible early Earth aqueous dry-down conditions. Both linear and branched co-polymers are produced. Mechanistic aspects of the reaction and potential roles of these polymers in prebiotic chemistry are discussed. Co-polymerization of glycol nucleic acid monomers with dicarboxylic acid linkers under plausible early Earth dry-down scenario conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc06818d