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Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1)-ones denitrogenative ring-opening of 3-aminoindazoles
A convenient and efficient copper-catalyzed oxidative arylation of quinoxalin-2(1 H )-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1 H )-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents via the cleavage of two C-N bonds. This oxida...
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| Published in: | New journal of chemistry 2023-02, Vol.47 (8), p.3783-3792 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
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| container_end_page | 3792 |
| container_issue | 8 |
| container_start_page | 3783 |
| container_title | New journal of chemistry |
| container_volume | 47 |
| creator | Mou, Chen-Xu Yuan, Jin-Wei Hu, Qian Han, Bing-Jie Yang, Liang-Ru Xiao, Yong-Mei Fan, Lu-Lu Zhang, Shou-Ren Qu, Ling-Bo |
| description | A convenient and efficient copper-catalyzed oxidative arylation of quinoxalin-2(1
H
)-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1
H
)-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents
via
the cleavage of two C-N bonds. This oxidative arylation of quinoxalin-2(1
H
)-ones involves a radical process and undergoes a sequence of 3-aminoindazole oxidation, two C-N bond cleavage, and cyanoaryl radical addition.
A convenient and efficient copper-catalyzed oxidative C3-cyanoarylation of quinoxalin-2(1
H
)-ones is developed using 3-aminoindazoles as efficient arylating agents
via
the cleavage of two C-N bonds. |
| doi_str_mv | 10.1039/d2nj04309b |
| format | article |
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H
)-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1
H
)-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents
via
the cleavage of two C-N bonds. This oxidative arylation of quinoxalin-2(1
H
)-ones involves a radical process and undergoes a sequence of 3-aminoindazole oxidation, two C-N bond cleavage, and cyanoaryl radical addition.
A convenient and efficient copper-catalyzed oxidative C3-cyanoarylation of quinoxalin-2(1
H
)-ones is developed using 3-aminoindazoles as efficient arylating agents
via
the cleavage of two C-N bonds.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d2nj04309b</identifier><ispartof>New journal of chemistry, 2023-02, Vol.47 (8), p.3783-3792</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Mou, Chen-Xu</creatorcontrib><creatorcontrib>Yuan, Jin-Wei</creatorcontrib><creatorcontrib>Hu, Qian</creatorcontrib><creatorcontrib>Han, Bing-Jie</creatorcontrib><creatorcontrib>Yang, Liang-Ru</creatorcontrib><creatorcontrib>Xiao, Yong-Mei</creatorcontrib><creatorcontrib>Fan, Lu-Lu</creatorcontrib><creatorcontrib>Zhang, Shou-Ren</creatorcontrib><creatorcontrib>Qu, Ling-Bo</creatorcontrib><title>Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1)-ones denitrogenative ring-opening of 3-aminoindazoles</title><title>New journal of chemistry</title><description>A convenient and efficient copper-catalyzed oxidative arylation of quinoxalin-2(1
H
)-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1
H
)-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents
via
the cleavage of two C-N bonds. This oxidative arylation of quinoxalin-2(1
H
)-ones involves a radical process and undergoes a sequence of 3-aminoindazole oxidation, two C-N bond cleavage, and cyanoaryl radical addition.
A convenient and efficient copper-catalyzed oxidative C3-cyanoarylation of quinoxalin-2(1
H
)-ones is developed using 3-aminoindazoles as efficient arylating agents
via
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H
)-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1
H
)-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents
via
the cleavage of two C-N bonds. This oxidative arylation of quinoxalin-2(1
H
)-ones involves a radical process and undergoes a sequence of 3-aminoindazole oxidation, two C-N bond cleavage, and cyanoaryl radical addition.
A convenient and efficient copper-catalyzed oxidative C3-cyanoarylation of quinoxalin-2(1
H
)-ones is developed using 3-aminoindazoles as efficient arylating agents
via
the cleavage of two C-N bonds.</abstract><doi>10.1039/d2nj04309b</doi><tpages>1</tpages></addata></record> |
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| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| title | Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1)-ones denitrogenative ring-opening of 3-aminoindazoles |
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