Synthesis and properties of hollow FeO@Au hybrid nano-structures for - MR imaging and a combination of magnetic and photo-induced heating

• Published in: New journal of chemistry 2023-02, Vol.47 (8), p.452-467
• Main Authors: Linh, Nguyen T. N, Dung, Ngo T, Tam, Le T. T, Tam, Le T, Hung, Nguyen P, Vinh, Nguyen D, Ha, Ngo T, Nam, Pham. H, Thanh, Le V, Dong, Nguyen V, Nam, Le G, Dang, Nguyen V, Phuc, Nguyen X, Tung, Le D, Thanh, Nguyen T. K, Lu, Le T
• Format: Article
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/d2nj04880a

In the current work, hollow Fe 3 O 4 @Au hybrid nanoparticles (h-NPs) with a size of 17 nm were synthesised through seeded growth and galvanic replacement reactions. The influence of the experimental parameters such as the reaction time and precursor concentration on the formation of h-NPs was investigated. The hydrophobic hollow Fe 3 O 4 @Au h-NPs were transferred into water by coating with an amphiphilic polymer, poly(maleic anhydride- alt -1-octadecene) (PMAO), to form highly stable colloids. The PMAO coated hollow Fe 3 O 4 @Au h-NPs provide an excellent signal enhancement of T 1 - and T 2 -weighted MRI ( r 1 = 8.47 mM −1 s −1 , r 2 = 74.45 mM −1 s −1 ). Magnetic and photothermal data of the hollow Fe 3 O 4 @Au h-NPs indicated that sample temperature can reach 70 °C under a magnetic field of 16 kA m −1 and a frequency of 450 kHz for 2 min and 808 nm NIR laser at a power density of 0.65 W cm −2 for 2 min. This effective combination between the magnetic thermia of the magnetic cores and the photothermal effect of the gold shell indicates hollow Fe 3 O 4 @Au h-NPs as a potential material for efficient cancer theranostics. The effective combination between the magnetic thermia of the magnetic cores and the photothermal effect of the gold shell indicates hollow PMAO coated Fe 3 O 4 @Au hybrid nanoparticles as a potential material for efficient cancer theranostics.