Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSOCFCOMe and EtN·3HF

Photoredox-catalyzed three-component fluorodifluoroacetylation of aromatic alkenes is reported, which features a wide substrate scope and functional group tolerance. An advantage of the reaction is the use of a nucleophilic fluoride source and a general difluoroacetylation reagent for the fluorodifl...

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Published in:Organic & biomolecular chemistry 2022-05, Vol.2 (18), p.3726-373
Main Authors: Zou, Song, Luo, Xuewei, Chen, Chao, Xi, Chanjuan
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Summary:Photoredox-catalyzed three-component fluorodifluoroacetylation of aromatic alkenes is reported, which features a wide substrate scope and functional group tolerance. An advantage of the reaction is the use of a nucleophilic fluoride source and a general difluoroacetylation reagent for the fluorodifluoroacetylation of alkenes. Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSO 2 CF 2 CO 2 Me and Et 3 N·3HF is disclosed. A range of the aromatic alkenes were transformed to the corresponding γ-fluorinated α,α-difluoroacetates in high yields with high regioselectivities.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob00488g