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Efficient synthesis of spiro diheterocycles multi-component dicyclization reaction
A facile synthetic protocol for the preparation of spiro diheterocycles from easily available 2′-aminoacetophenones, isocyanates and 1,4-benzoquinones or quinone monoimines under mild conditions has been developed. This multi-component transformation is characterized by efficient construction of two...
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| Published in: | Organic & biomolecular chemistry 2022-11, Vol.2 (43), p.8461-8464 |
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| Main Authors: | , , , , , |
| Format: | Article |
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| container_end_page | 8464 |
| container_issue | 43 |
| container_start_page | 8461 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 2 |
| creator | Wang, Lingfeng Zhao, Peng Li, Song Ma, Yongmin Zhang, Pengfei Xu, Weiming |
| description | A facile synthetic protocol for the preparation of spiro diheterocycles from easily available 2′-aminoacetophenones, isocyanates and 1,4-benzoquinones or quinone monoimines under mild conditions has been developed. This multi-component transformation is characterized by efficient construction of two heterocycles and one valuable quaternary carbon in one pot
via
an
in situ
cyclization-respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.
Spiro diheterocycles with one valuable quaternary carbon were constructed in one pot
via
an
in situ
cyclization-respiroannulation strategy. |
| doi_str_mv | 10.1039/d2ob01368a |
| format | article |
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via
an
in situ
cyclization-respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.
Spiro diheterocycles with one valuable quaternary carbon were constructed in one pot
via
an
in situ
cyclization-respiroannulation strategy.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/d2ob01368a</identifier><ispartof>Organic & biomolecular chemistry, 2022-11, Vol.2 (43), p.8461-8464</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Wang, Lingfeng</creatorcontrib><creatorcontrib>Zhao, Peng</creatorcontrib><creatorcontrib>Li, Song</creatorcontrib><creatorcontrib>Ma, Yongmin</creatorcontrib><creatorcontrib>Zhang, Pengfei</creatorcontrib><creatorcontrib>Xu, Weiming</creatorcontrib><title>Efficient synthesis of spiro diheterocycles multi-component dicyclization reaction</title><title>Organic & biomolecular chemistry</title><description>A facile synthetic protocol for the preparation of spiro diheterocycles from easily available 2′-aminoacetophenones, isocyanates and 1,4-benzoquinones or quinone monoimines under mild conditions has been developed. This multi-component transformation is characterized by efficient construction of two heterocycles and one valuable quaternary carbon in one pot
via
an
in situ
cyclization-respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.
Spiro diheterocycles with one valuable quaternary carbon were constructed in one pot
via
an
in situ
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via
an
in situ
cyclization-respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.
Spiro diheterocycles with one valuable quaternary carbon were constructed in one pot
via
an
in situ
cyclization-respiroannulation strategy.</abstract><doi>10.1039/d2ob01368a</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2022-11, Vol.2 (43), p.8461-8464 |
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| source | Royal Society of Chemistry |
| title | Efficient synthesis of spiro diheterocycles multi-component dicyclization reaction |
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