Ce-catalyzed regioselective synthesis of pyrazoles from 1,2-diols tandem oxidation and C-C/C-N bond formation

• Published in: Organic & biomolecular chemistry 2022-12, Vol.21 (1), p.59-64
• Main Authors: Pal, Chandan Kumar, Jena, Ashis Kumar
• Format: Article
• ISSN: 1477-0520; 1477-0539
• DOI: 10.1039/d2ob01996e

A novel and efficient cerium-catalyzed tandem oxidation and intermolecular ring cyclization of vicinal diols with hydrazones has been achieved for the regioselective synthesis of pyrazole derivatives. The corresponding 1,3-di- and 1,3,5-trisubstituted pyrazoles were obtained in moderate to excellent yields. The reaction has the advantages of mild conditions, easily available starting materials, broad substrate scope and good functional group tolerance. A novel and efficient cerium-catalyzed tandem oxidation and intermolecular ring cyclization of vicinal diols with hydrazones has been achieved for the regioselective synthesis of pyrazole derivatives.