Altereporenes AE, five epoxy octa-hydronaphthalene polyketides produced by an endophytic fungus sp. YUD20002

Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes AE ( 15 ) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum . Their structures were determined on the basis of comprehensive spectroscopic an...

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Published in:RSC advances 2022-08, Vol.12 (34), p.22295-2231
Main Authors: Xia, Dan-Dan, Duan, Hao-Jie, Xie, Fei, Xie, Tian-Peng, Zhang, Yan, Sun, Yue, Lu, Jian-Mei, Gao, Yu-Hong, Zhou, Hao, Ding, Zhong-Tao
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Summary:Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes AE ( 15 ) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum . Their structures were determined on the basis of comprehensive spectroscopic analyses, while the absolute configurations were elucidated by the comparison of experimental and calculated specific rotations. Meanwhile, the antimicrobial, cytotoxic, anti-inflammatory and acetylcholinesterase inhibitory activities of compounds 15 were also investigated. Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes AE ( 15 ) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum .
ISSN:2046-2069
DOI:10.1039/d2ra03917f