Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from sp. KCB15JA151

Two new polyketide glycosides jejuketomycins A ( 1 ) and B ( 2 ), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compoun...

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Published in:RSC advances 2022-08, Vol.12 (35), p.2236-22366
Main Authors: Jang, Jun-Pil, Kim, Gil Soo, Oh, Tae Hoon, Park, Beomcheol, Kim, Minhee, Hwang, Gwi Ja, Lee, Hyeok-Won, Lee, Jin-Gyeom, Hong, Young-Soo, Ahn, Jong Seog, Ko, Sung-Kyun, Jang, Jae-Hyuk
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Summary:Two new polyketide glycosides jejuketomycins A ( 1 ) and B ( 2 ), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity. Two new polyketide glycosides jejuketomycins A ( 1 ) and B ( 2 ), were isolated from a culture of Streptomyces sp. KCB15JA151.
ISSN:2046-2069
DOI:10.1039/d2ra04039e