Genetic encoding of isobutyryl-, isovaleryl-, and β-hydroxybutryl-lysine in

Here we report the synthesis and genetic encoding of the lysine post translational modifications, β-hydroxybutyryl-lysine, isobutyryl-lysine and isovaleryl-lysine. The ability to obtain a homogenous protein samples with site-specific incorporation of these acylated lysine residues can serve as a pow...

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Published in:RSC advances 2022-11, Vol.12 (53), p.34142-34144
Main Authors: Christopher, Jayani A, Galbada Liyanage, Sahan A, Nicholson, Eve M, Kinney, William D, Cropp, T. Ashton
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Summary:Here we report the synthesis and genetic encoding of the lysine post translational modifications, β-hydroxybutyryl-lysine, isobutyryl-lysine and isovaleryl-lysine. The ability to obtain a homogenous protein samples with site-specific incorporation of these acylated lysine residues can serve as a powerful tool to study the biological role of lysine post translational modifications. Here we report the synthesis and genetic encoding of the lysine post translational modifications, β-hydroxybutyryl-lysine, isobutyryl-lysine and isovaleryl-lysine.
ISSN:2046-2069
DOI:10.1039/d2ra04898a