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Potent antibacterial activity of MXene-functionalized graphene nanocomposites

Two dimensional (2D) nanomaterials display properties with significant biological utility ( e.g. , antimicrobial activity). In this study, MXene-functionalized graphene (FG) nanocomposites with Ti 3 C 2 T x in varying ratios (FG : Ti 3 C 2 T x , 25 : 75%, 50 : 50%, and 75 : 25%) were prepared and ch...

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Bibliographic Details
Published in:RSC advances 2022-11, Vol.12 (51), p.33142-33155
Main Authors: Salmi, Mohammed Sadey, Ahmed, Usman, Aslfattahi, Navid, Rahman, Saidur, Hardy, John George, Anwar, Ayaz
Format: Article
Language:English
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Summary:Two dimensional (2D) nanomaterials display properties with significant biological utility ( e.g. , antimicrobial activity). In this study, MXene-functionalized graphene (FG) nanocomposites with Ti 3 C 2 T x in varying ratios (FG : Ti 3 C 2 T x , 25 : 75%, 50 : 50%, and 75 : 25%) were prepared and characterized via scanning electron microscopy, scanning electron microscopy-energy dispersive X-ray (SEM-EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential analysis. Their cytotoxicity was assessed using immortalized human keratinocytes (HaCaT) cells at three different timepoints, and antibacterial activity was assessed using Gram-positive Methicillin resistant Staphylococcus aureus , MRSA, and Gram-negative neuro-pathogenic Escherichia coli K1 ( E. coli K1) in vitro . The nanomaterials and composites displayed potent antibacterial effects against both types of bacteria and low cytotoxicity against HaCaT cells at 200 μg mL −1 , which is promising for their utilization for biomedical applications. (A) SEM and (B) HRTEM images of 75% F graphene:25% Ti 3 C 2 T x nanocomposite.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra04944a