Polydopamine-functionalized selenium nanoparticles as an efficient photoresponsive antibacterial platform

• Published in: RSC advances 2023-03, Vol.13 (15), p.9998-14
• Main Authors: Sun, Meng, Gao, Ping, Wang, Bao, Li, Xiangyang, Shao, Donghan, Xu, Yan, Li, Leijiao, Li, Yunhui, Zhu, Jianwei, Li, Wenliang, Xue, Yingxue
• Format: Article
• Language: English
• Subjects: Biomedical materials; Chemistry; E coli; Materials selection; Nanoparticles; Selenium; Wound healing
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d2ra07737j

A photoresponsive therapeutic antibacterial platform was designed and constructed using polydopamine-functionalized selenium nanoparticles as a carrier loaded with indocyanine green (Se@PDA-ICG). The therapeutic platform was confirmed by characterization and the antibacterial activity of Se@PDA-ICG against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) was investigated. Under 808 nm laser irradiation, the antibacterial rate of Se@PDA-ICG against E. coli and S. aureus was 100% at 125 μg mL −1 . Furthermore, in a mouse wound infection model, the wound closure rate of the Se@PDA-ICG photoresponse group was 88.74% compared with 45.8% for the control group after 8 days of treatment, indicating that it could effectively kill bacteria and dramatically accelerate the wound healing process. These results suggested that Se@PDA-ICG could be a promising photo-activated antibacterial candidate material for biomedical applications. A photoresponsive synergistic therapy platform (Se@PDA-ICG) was constructed by loading indocyanine green on polydopamine functionalized selenium nanoparticles. It shows light response to kill bacteria and accelerates infected wound healing.