A copper-catalyzed four-component reaction of arylcyclopropanes, nitriles, carboxylic acids and -fluorobenzenesulfonimide: facile synthesis of imide derivatives

An unprecedented copper-catalyzed four-component reaction of arylcyclopropanes, nitriles, carboxylic acids and N -fluorobenzenesulfonimide (NFSI) has been successfully developed, which represents the first example of a four-component reaction of non-donor-acceptor cyclopropanes. A wide range of imid...

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Published in:Chemical science (Cambridge) 2022-11, Vol.13 (44), p.13117-13121
Main Authors: Yang, Shengbiao, Liu, Chunyang, Shangguan, Xiaoyan, Li, Yan, Zhang, Qian
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Summary:An unprecedented copper-catalyzed four-component reaction of arylcyclopropanes, nitriles, carboxylic acids and N -fluorobenzenesulfonimide (NFSI) has been successfully developed, which represents the first example of a four-component reaction of non-donor-acceptor cyclopropanes. A wide range of imide derivatives were efficiently synthesized in excellent yields under mild conditions. An unprecedented copper-catalyzed four-component reaction of arylcyclopropanes, nitriles, carboxylic acids and N -fluorobenzenesulfonimide (NFSI) has been successfully developed, efficiently synthesizing diverse imide derivatives.
ISSN:2041-6520
2041-6539
DOI:10.1039/d2sc04913a