ROS generation strategy based on biomimetic nanosheets by self-assembly of nanozymes

Reactive oxygen species (ROS) play an important role in physiology and have been applied in tumor therapy. However, insufficient endogenous H 2 O 2 and hypoxia in cancer cells can lead to limited ROS production and poor therapeutic efficacy. Herein, we develop a biomimetic nanosheet material based o...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2022-11, Vol.1 (46), p.967-9612
Main Authors: Ling, Pinghua, Yang, Pei, Gao, Xianping, Sun, Xinyu, Gao, Feng
Format: Article
Language:English
Subjects:
Apoptosis
Biomimetic materials
Biomimetics
Cascade chemical reactions
Catalase
Catalysis
Copper
External stimuli
Hydrogen Peroxide
Hypoxia
Nanosheets
Platinum
Reactive Oxygen Species
Self-assembly
Tumors
Ultrafines
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Summary:Reactive oxygen species (ROS) play an important role in physiology and have been applied in tumor therapy. However, insufficient endogenous H 2 O 2 and hypoxia in cancer cells can lead to limited ROS production and poor therapeutic efficacy. Herein, we develop a biomimetic nanosheet material based on the self-assembly of nanozymes that could supply H 2 O 2 under acidic conditions and catalyze a cascade of intracellular biochemical reactions to produce ROS under both normoxic and hypoxic conditions without any external stimuli. In this system, the copper peroxide nanosheets (CPNS), which are pH-responsive, were prepared through coordination of H 2 O 2 to Cu 2+ and then modified using ultrafine Pt NPs to form CPNS@Pt. The CPNS could decompose under acidic conditions, allowing the simultaneous release of Fenton catalytic Cu 2+ and H 2 O 2 accompanied by a Fenton-type reaction between them. On the other hand, Pt NPs were also released. The released Pt NPs behave as an oxidase mimic and catalase mimic. In this way, the well-defined CPNS@Pt can not only relieve hypoxic conditions but also generate ROS to induce cell apoptosis, thereby paving the way for the development of a nanozyme with multienzyme activity as a therapeutic strategy. Biomimetic nanosheets formed by the self-assembly of nanozymes were designed as a platform for ROS generation in cancer cells.
ISSN:2050-750X
2050-7518
DOI:10.1039/d2tb01639g