BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based...

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Bibliographic Details
Published in:RSC chemical biology 2024-01, Vol.5 (1), p.7-11
Main Authors: Lucana, Maria C, Lucchi, Roberta, Gosselet, Fabien, Díaz-Perlas, Cristina, Oller-Salvia, Benjamí
Format: Article
Language:English
Subjects:
Chemistry
Life Sciences
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Summary:Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier. BrainBikes, a new family of bicyclic brain shuttle peptides, can efficiently transport protein therapeutics across brain endothelium.
ISSN:2633-0679
2633-0679
DOI:10.1039/d3cb00194f