Aerobic oxidative C-H phosphorylation of quinoxalines under catalyst-free conditions

We herein report a direct and efficient protocol for phosphorylation of quinoxalines, which employs aerobic oxygen as the green oxidant under catalyst-free conditions. This methodology represents one of the most environmentally friendly and easily handled protocols, providing a series of phosphoryla...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-09, Vol.59 (74), p.1189-1192
Main Authors: Gan, Qiaoyu, Liu, Haibo, Jiang, Zeqi, Xia, Junmei, Gao, Zhenhua, Guo, Yongbiao, Wen, Hongliang
Format: Article
Language:English
Subjects:
Catalysts
Oxidizing agents
Phosphorylation
Quinoxalines
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Summary:We herein report a direct and efficient protocol for phosphorylation of quinoxalines, which employs aerobic oxygen as the green oxidant under catalyst-free conditions. This methodology represents one of the most environmentally friendly and easily handled protocols, providing a series of phosphorylated quinoxalines in good to excellent yields. Control experiments clearly indicated that the reaction followed a dearomatization-rearomatization strategy. We report an easily handled and environmentally friendly protocol for highly efficient phosphorylation of quinoxalines under mild and metal-free conditions employing air as the green oxidant via a dearomatization-rearomatization strategy.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc02848h