Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q

All aromatic C-H bonds of triphenylphosphine (PPh 3 ) were efficiently replaced by C-D bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D 2 O, an inexpensive deuterium source. Furthermore, non-radioactive and safe deuterium-incorporated Mito-Q (drug candidate) was prepared from deuterated PPh 3...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-10, Vol.59 (81), p.121-1213
Main Authors: Moriyama, Shogo, Mae, Miyu, Shibata, Daiki, Yamakoshi, Hiroyuki, Kajimoto, Shinji, Nakabayashi, Takakazu, Ishimoto, Takayoshi, Mogi, Kaiki, Sajiki, Hironao, Akai, Shuji, Sawama, Yoshinari
Format: Article
Language:English
Subjects:
Deuteration
Deuterium
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Summary:All aromatic C-H bonds of triphenylphosphine (PPh 3 ) were efficiently replaced by C-D bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D 2 O, an inexpensive deuterium source. Furthermore, non-radioactive and safe deuterium-incorporated Mito-Q (drug candidate) was prepared from deuterated PPh 3 and used for the live-cell Raman imaging to evaluate the mitochondrial uptake. All aromatic C-H bonds of triphenylphosphine (PPh 3 ) were efficiently replaced by C-D bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D 2 O, an inexpensive deuterium source.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc04410f