At on gold nanoparticles for targeted radionuclide therapy application

• Published in: Physical chemistry chemical physics : PCCP 2024-05, Vol.26 (17), p.12915-12927
• Main Authors: Tanudji, Jeffrey, Kasai, Hideaki, Okada, Michio, Ogawa, Tetsuo, Aspera, Susan M, Nakanishi, Hiroshi
• Format: Article
• Language: English
• ISSN: 1463-9076; 1463-9084
• DOI: 10.1039/d3cp05326a

Targeted alpha therapy (TAT) is a methodology that is being developed as a promising cancer treatment using the α-particle decay of radionuclides. This technique involves the use of heavy radioactive elements being placed near the cancer target area to cause maximum damage to the cancer cells while minimizing the damage to healthy cells. Using gold nanoparticles (AuNPs) as carriers, a more effective therapy methodology may be realized. AuNPs can be good candidates for transporting these radionuclides to the vicinity of the cancer cells since they can be labeled not just with the radionuclides, but also a host of other proteins and ligands to target these cells and serve as additional treatment options. Research has shown that astatine and iodine are capable of adsorbing onto the surface of gold, creating a covalent bond that is quite stable for use in experiments. However, there are still many challenges that lie ahead in this area, whether they be theoretical, experimental, and even in real-life applications. This review will cover some of the major developments, as well as the current state of technology, and the problems that need to be tackled as this research topic moves along to maturity. The hope is that with more workers joining the field, we can make a positive impact on society, in addition to bringing improvement and more knowledge to science. Targeted Alpha Therapy (TAT) using 211 At-AuNP is a new and growing field of multidisciplinary research that would ultimately provide the medical community with another way to treat cancer.