Harnessing the dual antimicrobial mode of action with a lipophilic Mn() complex using the principle of the Irving-Williams Series to completely eradicate

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn( ii ) ionophore results in the synthesis of Mn(BQ) 2 (DMSO) 2 ·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg...

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Published in:Dalton transactions : an international journal of inorganic chemistry 2023-09, Vol.52 (35), p.1223-1227
Main Authors: Mudarmah, Khalil, Bagale, Bijaya, Chen, Guanyu, Krause, Jeanette A, Mighion, Jeffrey D, Huang, Songping D
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Summary:The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn( ii ) ionophore results in the synthesis of Mn(BQ) 2 (DMSO) 2 ·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL −1 ). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria. Harnessing a dual antimicrobial mode of action in a novel Mn( ii )-complex: teaching an old dog new tricks using the Irving-Williams Series.
ISSN:1477-9226
1477-9234
DOI:10.1039/d3dt01904g