Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress

The enhancement of bioavailability of food bioactive compounds as dietary supplements can be achieved through the development of targeted delivery systems. This study aimed to develop a novel dual-targeted delivery system for hepatocytes and mitochondria using phacoemulsification self-assembly. The...

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Bibliographic Details
Published in:Food & function 2024-02, Vol.15 (4), p.2131-2143
Main Authors: Zhang, Xiumin, Shaukat, Mahwish, Liu, Ronggang, Peng, Liyang, Wang, Yuxiao, Su, Wentao, Song, Yukun, Tan, Mingqian
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Astaxanthin
Bioactive compounds
Bioavailability
Correlation coefficient
Correlation coefficients
Dietary Supplements
Galactose
Hepatocytes
Liver
Mice
Nanoparticles
Oligosaccharides
Oral administration
Organophosphorus Compounds
Oxidative Stress
Pharmacokinetics
Reactive oxygen species
Self-assembly
Whey protein
Xanthophylls
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Summary:The enhancement of bioavailability of food bioactive compounds as dietary supplements can be achieved through the development of targeted delivery systems. This study aimed to develop a novel dual-targeted delivery system for hepatocytes and mitochondria using phacoemulsification self-assembly. The delivery systems were engineered by modifying whey protein isolate (WPI) with galactose oligosaccharide (GOS) and triphenylphosphonium (TPP) to improve AXT transport to the liver and promote hepatic well-being. The dual-targeted nanoparticles (AXT@TPP-WPI-GOS) significantly reduced reactive oxygen species in in vitro experiments, thereby slowing down apoptosis. The AXT@TPP-WPI-GOS exhibited a prominent mitochondrial targeting capacity with a Pearson correlation coefficient of 0.76 at 4 h. In vivo pharmacokinetic experiments revealed that AXT@TPP-WPI-GOS could enhance AXT utilization by 28.18 ± 11.69%. Fluorescence imaging in mice demonstrated significantly higher levels of AXT@TPP-WPI-GOS accumulation in the liver compared to that of free AXT. Therefore, these nanoparticles hold promising applications in nutrient fortification, improving the bioavailability of AXT and supporting hepatic well-being. The enhancement of bioavailability of food bioactive compounds as dietary supplements can be achieved through the development of targeted delivery systems.
ISSN:2042-6496
2042-650X
DOI:10.1039/d3fo05319a