Photo-triggered halodecarboxylation of aliphatic carboxylic acids cerium-mediated ligand-to-metal charge transfer in water

A general catalytic protocol for the halodecarboxylation of aliphatic carboxylic acids via ligand-to-metal charge transfer (LMCT) is presented. This conversion is capable of transforming primary, secondary, and tertiary alkyl acids into the corresponding bromo-, iodo- and chloroalkanes using water a...

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Published in:Green chemistry : an international journal and green chemistry resource : GC 2023-10, Vol.25 (21), p.8741-8747
Main Authors: Xu, Yan, Huang, Panyi, Jiang, Yu, Lv, Chun, Li, Peixuan, Wang, Jiayang, Sun, Bin, Jin, Can
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Summary:A general catalytic protocol for the halodecarboxylation of aliphatic carboxylic acids via ligand-to-metal charge transfer (LMCT) is presented. This conversion is capable of transforming primary, secondary, and tertiary alkyl acids into the corresponding bromo-, iodo- and chloroalkanes using water as a solvent under an air atmosphere. The broad range of substrate scope, the use of a green solvent, and the ability to derivatize drug molecules and natural products offer a new prospect for decarboxylative halogenation reactions. An efficient photo-triggered halodecarboxylation reaction of aliphatic carboxylic acids for the preparation of bromo-, iodo- and chloroalkanes under an air atmosphere with water as the solvent has been developed.
ISSN:1463-9262
1463-9270
DOI:10.1039/d3gc02063k