Pumpless deterministic lateral displacement separation using a paper capillary wick

Deterministic lateral displacement (DLD) is a passive separation method that separates particles by hydrodynamic size. This label-free method is a promising technique for cell separation because of its high size resolution and insensitivity to flow rate. Development of capillary-driven microfluidic...

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Bibliographic Details
Published in:Lab on a chip 2023-04, Vol.23 (8), p.216-2112
Main Authors: Aghajanloo, Behrouz, Ejeian, Fatemeh, Frascella, Francesca, Marasso, Simone L, Cocuzza, Matteo, Tehrani, Alireza Fadaei, Nasr Esfahani, Mohammad Hossein, Inglis, David W
Format: Article
Language:English
Subjects:
Capillary flow
Capillary pressure
Flow stability
Flow velocity
Lateral displacement
Microfluidic devices
Separation
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Summary:Deterministic lateral displacement (DLD) is a passive separation method that separates particles by hydrodynamic size. This label-free method is a promising technique for cell separation because of its high size resolution and insensitivity to flow rate. Development of capillary-driven microfluidic technologies allows microfluidic devices to be operated without any external power for fluid pumping, lowering their total cost and complexity. Herein, we develop and test a DLD-based particle and cell sorting method that is driven entirely by capillary pressure. We show microchip self-filling, flow focusing, flow stability, and capture of separated particles. We achieve separation efficiency of 92% for particle-particle separation and more than 99% efficiency for cell-particle separation. The high performance of driven flow and separation along with simplicity of the operation and setup make it a valuable candidate for point-of-care devices. We demonstrate a highly efficient DLD separation device and process that is driven by a paper wick yet allows direct collection of products from reservoirs.
ISSN:1473-0197
1473-0189
DOI:10.1039/d3lc00039g