Development of a by-product-free strategy for the synthesis of oxazoline from -acetylglucosamine

This study focused on the CDMBI-mediated synthesis of GlcNAc oxazoline. Through our research, we uncovered and characterized a previously unreported by-product. We proposed a mechanism for its formation and developed a new strategy to prevent its occurrence. These findings represent an important ste...

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Bibliographic Details
Published in:New journal of chemistry 2023-05, Vol.47 (2), p.9532-9535
Main Authors: Zhou, Sen, Bo, Ma, Tang, Feng, Liu, Wenqiang, Li, Xin, Chen, Baoquan, Shang, Shiying, Huang, Wei, Li, Yaohao, Tan, Zhongping
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Summary:This study focused on the CDMBI-mediated synthesis of GlcNAc oxazoline. Through our research, we uncovered and characterized a previously unreported by-product. We proposed a mechanism for its formation and developed a new strategy to prevent its occurrence. These findings represent an important step towards gaining a deeper understanding of this reaction and may provide a new avenue for optimizing the oxazoline synthesis. This study focused on the CDMBI-mediated synthesis of GlcNAc oxazoline.
ISSN:1144-0546
1369-9261
DOI:10.1039/d3nj01323e