An endoplasmic reticulum-targeted fluorescent probe for ratiometric tracking of endogenous SO derivatives

A novel fluorescent probe (JSS-1) for endogenous SO 2 derivatives was developed by using 1,8-naphthalimide and malononitrile dyes on the basis of FRET and the ICT mechanism. JSS-1 possessed excellent photo-stability, deep-red emission signal, large Stokes shift and broad emission window gap. Additio...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2024-02, Vol.48 (7), p.292-2926
Main Authors: Yan, Yehao, Gong, Weilei, Li, Ruiji, Sun, Jiannan, Wang, Hua, He, Xiaoying, Si, Yanmei
Format: Article
Language:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel fluorescent probe (JSS-1) for endogenous SO 2 derivatives was developed by using 1,8-naphthalimide and malononitrile dyes on the basis of FRET and the ICT mechanism. JSS-1 possessed excellent photo-stability, deep-red emission signal, large Stokes shift and broad emission window gap. Additionally, it displayed various superiorities in sensing SO 2 derivatives, including low sensing limit, high sensitivity and selectivity. Significantly, JSS-1 was successfully employed to track endogenous SO 2 derivatives in the endoplasmic reticulum with a high co-localization coefficient of 0.93, and could even be used for the recognition of liver cancer cells. A novel fluorescent probe (JSS-1) for endogenous SO 2 derivatives was developed by using 1,8-naphthalimide and malononitrile dyes on the basis of FRET and the ICT mechanism.
ISSN:1144-0546
1369-9261
DOI:10.1039/d3nj04985j