Ring forming transformations of ynamides cycloaddition

• Published in: RSC advances 2023-04, Vol.13 (16), p.1715-1756
• Main Authors: Iftikhar, Ramsha, Mazhar, Aqsa, Iqbal, Muhammad Saqlain, Khan, Faiza Zahid, Askary, Syed Hassan, Sibtain, Hifza
• Format: Article
• ISSN: 2046-2069
• DOI: 10.1039/d3ra00139c

Ynamides are N -alkyne compounds bearing an electron withdrawing group at the nitrogen atom. They offer unique pathways for the construction of versatile building blocks owing to their exceptional balance between reactivity and stability. Recently several studies have been reported that explore and illustrate the synthetic potential of ynamides and ynamide-derived advanced intermediates in cycloadditions with different reaction partners to yield heterocyclic cycloadducts of synthetic and pharmaceutical value. Cycloaddition reactions of ynamides are the facile and preferable routes for the construction of structural motifs having striking importance in synthetic, medicinal chemistry, and advanced materials. In this systematic review, we highlighted the recently reported novel transformations and synthetic applications that involved the cycloaddition reaction of ynamides. The scope along with the limitations of the transformations are discussed in detail. Synthetic potential of ynamides and ynamide-derived advanced intermediates in cycloaddition reactions with different reaction partners to yield versatile heterocyclic adducts.