Microwave-assisted commercial copper-catalyzed aerobic oxidative synthesis of AChE quinazolinone inhibitors under solvent free conditions

A facile and green one-pot synthesis of AChE quinazolinone inhibitors was developed using microwave irradiation under solvent free conditions. Quinazolinones were synthesized from 2-aminobenzamide derivatives and various alcohols such as benzyl alcohol derivatives and butanol using economical commer...

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Bibliographic Details
Published in:RSC advances 2023-09, Vol.13 (39), p.27657-27662
Main Authors: Jongcharoenkamol, Jira, Naksing, Prakansi, Nimnuan, Nattayaporn, Singh, Thishana, Chatwichien, Jaruwan, Temkitthawon, Prapapan, Sriwattanawarunyoo, Chanitsara, Choommongkol, Vachira, Meepowpan, Puttinan, Kerdphon, Sutthichat
Format: Article
Language:English
Subjects:
Benzyl alcohol
Butanol
Chemical synthesis
Chemistry
Copper
Inhibitors
Quinazolinones
Solvents
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Summary:A facile and green one-pot synthesis of AChE quinazolinone inhibitors was developed using microwave irradiation under solvent free conditions. Quinazolinones were synthesized from 2-aminobenzamide derivatives and various alcohols such as benzyl alcohol derivatives and butanol using economical commercially available copper as a catalyst in the presence of base, Cs 2 CO 3 . The desired products were achieved in moderate to high yields with up to 92% isolated yield. These quinazolinone products were then evaluated for acetylcholinesterase inhibition so that they can be developed as promising anti-acetylcholinesterase agents. A facile and green one-pot synthesis of AChE quinazolinone inhibitors was developed using microwave irradiation under solvent free conditions.
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra05739a