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A dual responsive novel bipyridyl carbohydrazide Schiff base as a colorimetric-fluorescent probe for In and Al ions and its potential applications
The development of a probe for the selective recognition of trivalent cations Al 3+ and In 3+ has recently received greater attention due to the crucial roles these metal ions play in many biotic and material processes. In this regard, [2,2′-bipyridine] 6,6′-dicarbohydrazide has been designed to syn...
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| Published in: | Sensors & diagnostics 2024-03, Vol.3 (3), p.455-467 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Online Access: | Get full text |
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| Summary: | The development of a probe for the selective recognition of trivalent cations Al
3+
and In
3+
has recently received greater attention due to the crucial roles these metal ions play in many biotic and material processes. In this regard, [2,2′-bipyridine] 6,6′-dicarbohydrazide has been designed to synthesize a Schiff-base (
L
) using diethyl amino salicylaldehyde for the selective detection of Al
3+
and In
3+
. The probe
L
exhibits selective colorimetric response at 444 nm with In
3+
and turn-on fluorescence response at 497 nm with Al
3+
in DMSO : H
2
O (7 : 3, pH = 7.4). The probe
L
could form a 1 : 2 [L : M] stoichiometry complex confirmed by Job's plot and ESI mass analysis with an estimated association constant of 9.38 × 10
3
M
−2
and 4.75 × 10
4
M
−2
with Al
3+
and In
3+
ions, respectively. The probe could detect Al
3+
and In
3+
down to 10.98 nM and 110 nM without much interference from other common interfering ions. Inhibition of C&z.dbd;N isomerization and chelation-enhanced fluorescence (CHEF) could be induced to vary the photophysical properties of
L
upon interaction with Al
3+
, whereas, the
L
with In
3+
, exhibits ligand-to-metal charge transfer (LMCT) due to the presence of vacant f-orbitals. The binding mechanism of probe
L
with metal ions was investigated using
1
H NMR, mass, and DFT studies. More importantly, the potential application of probe
L
could be used to quantify Al
3+
and In
3+
in water samples and Al
3+
in
Dr
G cells and a zebrafish
in vivo
imaging model.
The development of a probe for the selective recognition of trivalent cations Al
3+
and In
3+
has recently received greater attention due to the crucial roles these metal ions play in many biotic and material processes. |
|---|---|
| ISSN: | 2635-0998 |
| DOI: | 10.1039/d3sd00282a |